Description

[S(R)]-n-[(S)-[3,5-Bis(Trifluoromethyl)Phenyl][2- (Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric catalysis. This compound matters for its ability to impart high enantioselectivity and catalytic efficiency in transition metal-catalyzed reactions, enabling the synthesis of complex, single-enantiomer molecules. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require precise stereochemical control for developing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed asymmetric cross-coupling to form C-C bonds with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug candidates, including those for oncology and central nervous system (CNS) disorders.
• Fine Chemical Production: Used in the manufacture of high-value agrochemicals, flavors, and fragrances requiring specific enantiomeric purity.
• Academic & Process Chemistry Research: A valuable tool for developing new catalytic methodologies and optimizing synthetic routes in R&D laboratories.
• Catalyst Screening Libraries: Serves as a high-performance component in catalyst libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	[S(R)]-n-[(S)-[3,5-Bis(Trifluoromethyl)Phenyl][2- (Diphenylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2262535-73-7
Molecular Formula	C31H26F6NOPS
Molecular Weight	605.57 g/mol
Synonyms	(SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl](2-diphenylphosphinophenyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphino)phenyl]methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type Sulfinamide Ligand; Asymmetric Hydrogenation Ligand; P,N-Ligand; CAS 2262535-73-7.
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality management systems to ensure exceptional purity and performance consistency. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity, chemical purity, and identity confirmation. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.