Description

L-Glutamic Acid, n-[(3S)-23-Amino-3-Carboxy-1,9-Dioxo-12,15,18,21-Tetraoxa-2,8-Diazatricos-1-Yl]- is a specialized, high-purity synthetic derivative of glutamic acid, engineered for advanced research and pharmaceutical development. This compound is valued for its precise molecular structure, which incorporates a polyether linker and reactive termini, making it a critical intermediate for targeted drug delivery systems and bioconjugation. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic institutions focused on developing novel therapeutics, diagnostic agents, and sophisticated chemical probes.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing antibody-drug conjugates (ADCs) and other targeted biopharmaceuticals.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or antibodies via its amino and carboxyl groups.
• Drug Delivery Systems: Serves as a component in the design of prodrugs and nanocarrier systems to improve solubility and target specificity.
• Proteomics Research: Employed in the development of chemical probes and affinity tags for studying protein function and interactions.
• Diagnostic Agent Synthesis: Used in the creation of contrast agents and molecular imaging probes for diagnostic applications.
• Peptide Engineering: Incorporated into synthetic peptides to introduce specific functional handles or modify physicochemical properties.

Basic Information

Product Name	L-Glutamic Acid, n-[(3S)-23-Amino-3-Carboxy-1,9-Dioxo-12,15,18,21-Tetraoxa-2,8-Diazatricos-1-Yl]-
CAS No.	2256069-92-6
Molecular Formula	C24H43N3O12
Molecular Weight	565.61 g/mol
Synonyms	N-[(3S)-23-Amino-3-carboxy-1,9-dioxo-12,15,18,21-tetraoxa-2,8-diazatricos-1-yl]-L-glutamic acid; Glutamic Acid Derivative with PEG Linker; Fmoc-Glu(OPEG-amine)-OH derivative; (S)-2-((S)-2-Amino-23-((carboxymethyl)amino)-3,6,9,12,15,18-hexaoxa-21-azatricosanoyl)amino)pentanedioic acid; Polyethylene glycol glutamic acid derivative; ADC Linker-Glutamic Acid Conjugate; Custom PEGylated amino acid; Research-grade bioconjugation reagent.
EINECS	Contact for details

Quality Control

Every batch of our L-Glutamic Acid derivative is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for each lot, which include data from HPLC, NMR, and Mass Spectrometry analyses. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature between -20°C to -10°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.