Description

Fmoc-L-n-Methyl-o-(Difluoromethyl)-Tyrosine is a sophisticated, non-natural amino acid derivative engineered for advanced peptide synthesis and pharmaceutical research. This compound is specifically designed to introduce a unique, metabolically stable difluoromethylphenol moiety into peptide chains, enhancing binding affinity and resistance to enzymatic degradation. It is an essential building block for medicinal chemists and researchers in drug discovery, particularly for developing novel therapeutics targeting proteases, kinases, and protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the incorporation of a modified tyrosine residue.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide-based drug candidates, peptidomimetics, and chemical probes where the difluoromethyl group improves metabolic stability and lipophilicity.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled peptides for biochemical assays and imaging studies.
• Pharmaceutical Intermediate: A critical raw material in the research and development stages of novel oncology, antiviral, and metabolic disease therapeutics.
• Academic and Institutional Research: Utilized in universities and R&D institutes for studying enzyme mechanisms, receptor-ligand interactions, and structure-activity relationships (SAR).
• Peptide Library Construction: Employed in combinatorial chemistry to generate diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	Fmoc-L-n-Methyl-o-(Difluoromethyl)-Tyrosine
CAS No.	2255321-53-8
Molecular Formula	C27H25F2NO6
Molecular Weight	497.49 g/mol
Synonyms	Fmoc-N-Me-Tyr(2-CHF2)-OH; Fmoc-N-Methyl-O-(difluoromethyl)tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(difluoromethyl)-L-tyrosine; (2S)-3-[4-(Difluoromethoxy)phenyl]-2-[(9H-fluoren-9-ylmethoxy)formamido]methylpropanoic acid; Fmoc-L-N-Me-Tyr(CHF2)-OH; Fmoc-N-Me-2,6-difluoro-Tyr-OH (common misnomer); N-Fmoc-N-methyl-O-difluoromethyl-L-tyrosine; Fmoc-N-methyl-O-(difluoromethyl)-L-phenylalanine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-n-Methyl-o-(Difluoromethyl)-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.