Description

S(R)]-n-[(1S)-1-[2-(Dicyclohexylphosphino)Phenyl]Ethyl]-N,2-Dimethyl-2-Propanesulfinamide is a high-value, chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. Its primary value lies in its ability to act as a highly effective and selective ligand for transition metal catalysts, enabling the production of enantiomerically pure compounds. This makes it an indispensable tool for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic routes. The compound, identified by CAS No. 2253984-97-1, is designed for applications demanding high enantioselectivity and yield.

Application

This specialized ligand is engineered for advanced catalytic processes. Its primary and related applications include:

• Asymmetric Hydrogenation: A key ligand for catalyzing the enantioselective addition of hydrogen to prochiral substrates like olefins, ketones, and imines, crucial for creating chiral active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Used in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings to form carbon-carbon and carbon-heteroatom bonds with high stereofidelity.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers through nucleophilic attack on allylic systems, a valuable method in complex molecule synthesis.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and scalable production of single-enantiomer intermediates for drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Active Ingredient Development: Applied in the synthesis of chiral herbicides, fungicides, and pesticides where specific stereochemistry is linked to biological activity.
• Academic & Process Chemistry Research: Serves as a benchmark ligand in methodological development and optimization of new asymmetric transformations.

Basic Information

Product Name	S(R)]-n-[(1S)-1-[2-(Dicyclohexylphosphino)Phenyl]Ethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2253984-97-1
Molecular Formula	C25H42NOPS
Molecular Weight	435.66 g/mol
Synonyms	(S)-N-[(1S)-1-[2-(Dicyclohexylphosphino)phenyl]ethyl]-N,2-dimethylpropane-2-sulfinamide; (S)-N-((S)-1-(2-(Dicyclohexylphosphino)phenyl)ethyl)-N,2-dimethylpropane-2-sulfinamide; Sulfinamide-Phosphine Hybrid Ligand; Chiral Sulfinamide Phosphine Ligand; Josiphos-type Sulfinamide Ligand; Asymmetric Hydrogenation Ligand; CAS 2253984-97-1
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries, ensuring traceability and reliability from gram to kilogram scale.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at 2-8°C under an inert atmosphere (argon or nitrogen) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.