Description

Resiquimod D5 is a deuterated analog of the potent immune response modifier, Resiquimod, designed for use as an internal standard in analytical research. This high-purity compound is essential for ensuring accurate quantification and method validation in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of Resiquimod in complex biological matrices via liquid chromatography-tandem mass spectrometry.
• Bioanalytical Method Development: Used in the development and validation of robust analytical methods for drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmaceutical Research: Supports preclinical and clinical research programs focused on toll-like receptor 7/8 (TLR7/8) agonists by enabling accurate drug level monitoring.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based assays.
• Quality Control in API Manufacturing: Can be employed as a reference standard in the quality control of active pharmaceutical ingredient (API) batches.

Basic Information

Item	Detail
Product Name	Resiquimod D5
CAS No.	2252319-44-9
Molecular Formula	C17H17D5N4O2
Molecular Weight	307.40 g/mol (for C17H17D5N4O2)
Synonyms	R-848 D5; S-28463 D5; 4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol D5; 1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol D5; TLR7/8 Agonist D5; Deuterated Resiquimod; Resiquimod-d5
EINECS	Contact for details

Quality Control

Every batch of Resiquimod D5 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Certificates of Analysis (COA) are provided with each shipment, detailing results from NMR, HPLC, and MS analysis to confirm identity, purity, and deuterium incorporation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.