Description

(S)-2-(Piperazin-2-Yl)Acetonitrile Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure molecules, offering a distinct advantage in developing targeted therapeutics with specific biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas like neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a building block for constructing complex, enantiomerically pure molecules in medicinal chemistry.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in stereoselective transformations.
• Peptidomimetic Research: Incorporated into the design of peptide analogs and mimetics to modulate biological activity and stability.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization during the transition from laboratory to pilot and commercial-scale manufacturing.

Basic Information

Product Name	(S)-2-(Piperazin-2-Yl)Acetonitrile Hydrochloride
CAS No.	2250243-13-9
Molecular Formula	C6H12N3·HCl
Molecular Weight	161.64 (Free base) / 198.10 (HCl salt)
Synonyms	(S)-2-(Piperazin-2-yl)acetonitrile hydrochloride; (2S)-2-(Piperazin-2-yl)acetonitrile monohydrochloride; (S)-Piperazine-2-acetonitrile hydrochloride; 2-(Piperazin-2-yl)acetonitrile, (S)-, hydrochloride; (S)-2-(1-Piperazinyl)acetonitrile hydrochloride; (S)-Aminomethylpiperazine acetonitrile hydrochloride; (S)-2-Piperazineacetonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-(Piperazin-2-Yl)Acetonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.