Description

(R)-2-(Piperazin-2-Yl)Acetonitrile Dihydrochloride CAS NO 2250242-66-9 is a high-purity chiral piperazine derivative, specifically the (R)-enantiomer, offered as a stable dihydrochloride salt. This compound serves as a critical chiral building block and intermediate in the synthesis of complex, biologically active molecules. It is primarily utilized by pharmaceutical research and development organizations, agrochemical innovators, and advanced material scientists for applications requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of enantiomerically pure pesticides and herbicides where specific stereochemistry is essential for efficacy and environmental safety.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring a defined chiral piperazine core.
• Academic & Institutional Research: Used in medicinal chemistry programs and methodological studies focused on nitrogen heterocycles and chiral amine chemistry.

Basic Information

Product Name	(R)-2-(Piperazin-2-Yl)Acetonitrile Dihydrochloride
CAS No.	2250242-66-9
Molecular Formula	C6H12N4 · 2HCl
Molecular Weight	209.11 g/mol (Free base: 138.19 g/mol)
Synonyms	(R)-2-(Piperazin-2-yl)acetonitrile dihydrochloride; (2R)-2-(Piperazin-2-yl)acetonitrile dihydrochloride; (R)-Piperazine-2-acetonitrile dihydrochloride; (R)-2-Piperazinylacetonitrile dihydrochloride; 2250242-66-9; (R)-2-Cyanomethylpiperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(Piperazin-2-Yl)Acetonitrile Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.