Description

Bocnh-Peg3-Ch2Ch2Coonhs CAS NO 2250216-93-2 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (Boc) protected amine at one terminus and an N-hydroxysuccinimide (NHS) ester at the other. This compound is engineered for the controlled conjugation of biomolecules, offering a hydrophilic spacer arm to enhance solubility and reduce steric hindrance. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, enabling the synthesis of stable, well-defined conjugates for drug delivery systems and diagnostic assays.

Application

• Bioconjugation and Crosslinking: Used to covalently link amines on peptides, proteins, or antibodies with other functional groups, creating stable antibody-drug conjugates (ADCs) or protein-polymer hybrids.
• Drug Delivery System Development: Serves as a key building block for constructing PEGylated drug carriers, liposomes, and nanoparticles to improve pharmacokinetics and target specificity.
• Proteomics Research: Facilitates the labeling and modification of proteins for analytical studies, affinity purification, and surface immobilization.
• Diagnostic Reagent Synthesis: Employed in the production of enzyme-linked immunosorbent assay (ELISA) components, fluorescent probes, and other diagnostic tools.
• Biomaterial Functionalization: Used to introduce reactive NHS ester groups onto surfaces, hydrogels, or scaffolds for subsequent biomolecule attachment.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a cleavable, hydrophilic linker during the synthesis of complex peptides.

Basic Information

Product Name	Bocnh-Peg3-Ch2Ch2Coonhs
CAS No.	2250216-93-2
Molecular Formula	C23H40N2O10
Molecular Weight	504.58 g/mol
Synonyms	Boc-NH-PEG3-CH2CH2COOH NHS ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]ethoxy]propanoate; Boc-Amine-PEG3-Propionic Acid NHS Ester; Boc-N-amido-PEG3-C2-acid NHS ester; Boc-NH-PEG3-C2-NHS; tert-Butyl (8-hydroxy-3,6-dioxaoctyl)carbamate NHS ester derivative; Boc-protected PEG3 NHS ester; Heterobifunctional PEG linker Boc-NHS
EINECS	Contact for details

Quality Control

Our Bocnh-Peg3-Ch2Ch2Coonhs is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development under cGMP guidelines for applications requiring the highest level of quality assurance and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis of the active NHS ester. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.