Description

[S(R)]-n-[(R)-[2-(Diadamantanphosphino)Phenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide ligand incorporating a bulky diadamantylphosphino group. This compound matters as a highly selective and efficient catalyst ligand for asymmetric synthesis, enabling the production of enantiomerically pure intermediates critical for advanced pharmaceuticals. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for challenging transition-metal catalyzed reactions such as cross-couplings and hydrogenations.

Application

• As a chiral ligand in asymmetric transition-metal catalysis (e.g., Pd, Rh, Ir).
• For the enantioselective synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• In asymmetric hydrogenation reactions to create chiral centers with high enantiomeric excess (ee).
• For cross-coupling reactions (e.g., Suzuki, Heck) requiring sterically demanding and electron-rich phosphine ligands.
• As a key building block in the development of novel catalyst systems for academic and industrial research.
• In the synthesis of specialty fine chemicals and agrochemicals where stereochemical control is paramount.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Diadamantanphosphino)Phenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2249950-31-8
Molecular Formula	C40H47NOPS
Molecular Weight	605.84 g/mol
Synonyms	(S)-N-((R)-(2-(Diadamantylphosphino)phenyl)(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide; (S)-N-((R)-(2-(Diadamantan-1-ylphosphino)phenyl)(1-naphthyl)methyl)-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1R)-[2-(di-1-adamantylphosphino)phenyl]-1-naphthalenylmethyl]-; Diadamantylphosphino Sulfinamide Ligand; Chiral Sulfinamide-Phosphine Hybrid Ligand; CAS 2249950-31-8
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous quality testing to ensure identity, purity, and enantiomeric excess meet the stringent requirements for catalysis research and development. Standard analytical techniques include HPLC, 1H/31P/13C NMR, and chiral HPLC analysis to verify structural integrity and stereochemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The compound is easily oxidized and moisture-sensitive; therefore, containers should be flushed with inert gas after each opening and stored in a cool, dry place. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.