Description

(S)-3,3'-Bis(2-Naphthyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogen Phosphate is a high-value, chiral phosphoric acid derivative, a key class of organocatalysts. It matters for its ability to provide exceptional enantioselectivity and reaction efficiency in asymmetric synthesis, a cornerstone of modern pharmaceutical and fine chemical manufacturing. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity chiral catalysts to develop novel active ingredients and specialty chemicals.

Application

• Asymmetric Organocatalysis: Serving as a privileged Brønsted acid catalyst for a wide range of enantioselective transformations, including Friedel-Crafts alkylations, Mannich reactions, and transfer hydrogenations.
• Pharmaceutical Intermediate Synthesis: Critical for the stereoselective construction of complex chiral scaffolds found in active pharmaceutical ingredients (APIs), enabling more efficient and sustainable drug development pathways.
• Agrochemical Research: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators, where specific stereochemistry is crucial for efficacy and environmental safety.
• Chiral Ligand Precursor: Can be modified or used as a precursor to develop novel chiral ligands for transition metal catalysis, expanding the toolbox for asymmetric synthesis.
• Material Science: Potential application in the development of chiral stationary phases for analytical chromatography or chiral dopants for liquid crystalline materials.
• Academic & Industrial R&D: A vital reagent for method development and discovery chemistry in both university laboratories and corporate research centers focused on asymmetric synthesis.

Basic Information

Item	Details
Product Name	(S)-3,3'-Bis(2-Naphthyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogen Phosphate
CAS No.	2249931-95-9
Molecular Formula	C44H35O4P
Molecular Weight	658.72 g/mol
Synonyms	(S)-3,3'-Di(2-naphthyl)-H8-BINOL Phosphoric Acid; (S)-H8-BINOL-Derived Phosphoric Acid Catalyst; (S)-3,3'-Bis(naphthalen-2-yl)-5,5',6,6',7,7',8,8'-octahydro-[1,1'-binaphthalene]-2,2'-diyl Hydrogen Phosphate; (S)-H8-BINOL-Based Chiral Phosphoric Acid; (S)-Octahydro-BINOL Phosphoric Acid Derivative; Chiral Brønsted Acid Catalyst; Asymmetric Organocatalyst; (S)-TRIP Analog (H8-Series)
EINECS	Contact for details

Quality Control

Every batch of our (S)-3,3'-Bis(2-Naphthyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl-2,2'-Diyl Hydrogen Phosphate is produced and tested under a strict quality management system. We ensure high chiral purity and chemical integrity through comprehensive analytical techniques including HPLC, NMR, and specific rotation measurement. Certificates of Analysis (COA) with full batch traceability are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.