Description

Cyclobutane, 1-Bromo-3-(Trifluoromethyl)- is a high-value, halogenated cyclobutane derivative that serves as a critical building block in advanced organic synthesis. This compound is specifically engineered to introduce both bromine and trifluoromethyl functional groups into molecular frameworks, enabling the development of novel materials and active compounds with tailored properties. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty materials industries for creating next-generation products.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic semiconductors and liquid crystal molecules used in display technologies.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex biaryl structures.
• Fluorine Chemistry Exploration: A valuable reagent for academic and industrial research focused on introducing fluorine atoms into complex organic molecules.

Basic Information

Product Name	Cyclobutane, 1-Bromo-3-(Trifluoromethyl)-
CAS No.	2247103-30-4
Molecular Formula	C5H6BrF3
Molecular Weight	203.00 g/mol
Synonyms	1-Bromo-3-(trifluoromethyl)cyclobutane; 3-(Trifluoromethyl)cyclobutyl bromide; (3-(Trifluoromethyl)cyclobutyl)bromide; Bromo(3-(trifluoromethyl)cyclobutane); Cyclobutane, bromo(trifluoromethyl)-; 1-Bromo-3-trifluoromethyl-cyclobutane
EINECS	Contact for details

Quality Control

Our production of Cyclobutane, 1-Bromo-3-(Trifluoromethyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR, GC-MS, and HPLC analysis, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for specific research or production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and transfers should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.