Description

2-(4-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern organic synthesis, valued for its role in facilitating key carbon-carbon bond-forming reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients. Its specific structure makes it essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone of medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for constructing biaryl and heterobiaryl scaffolds essential in medicinal chemistry.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, including herbicides and fungicides.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Acts as a functional handle for bioconjugation and the development of chemical probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-(4-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246693-81-0
Molecular Formula	C20H22BF2O3
Molecular Weight	359.20 g/mol
Synonyms	4-((3,5-Difluorobenzyl)oxy)phenylboronic acid pinacol ester; 2-[4-[(3,5-Difluorophenyl)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-((3,5-Difluorobenzyl)oxy)phenyl)boronic acid pinacol ester; 3,5-Difluorobenzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; B-[4-[(3,5-Difluorobenzyl)oxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborinane; DFBP Boronic Ester; PINACOL (4-((3,5-DIFLUOROBENZYL)OXY)PHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 2-(4-((3,5-Difluorobenzyl)Oxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.