Description

2-[2-(Benzyloxy)-4-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 2246670-77-7 is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality precursors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage the stability and reactivity of the boronate ester group.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its ability to form conjugated systems.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Academic & Industrial R&D: A staple reagent in laboratory-scale and process chemistry for method development and scaling novel synthetic routes.
• Ligand and Catalyst Preparation: Can be utilized in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Item	Details
Product Name	2-[2-(Benzyloxy)-4-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2246670-77-7
Molecular Formula	C19H22BFO3
Molecular Weight	328.19 g/mol
Synonyms	4-Fluoro-2-(benzyloxy)phenylboronic acid pinacol ester; (2-(Benzyloxy)-4-fluorophenyl)boronic acid pinacol ester; 2-(Benzyloxy)-4-fluorophenylboronic acid pinacol ester; 4-Fluoro-2-(phenylmethoxy)benzeneboronic acid pinacol ester; B-[2-(Benzyloxy)-4-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(Benzyloxy)-4-fluorobenzeneboronic acid pinacol ester; PINACOL 2-(BENZYLOXY)-4-FLUOROPHENYLBORONATE
EINECS	Contact for details

Quality Control

Our 2-[2-(Benzyloxy)-4-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH, FDA guidelines for drug substances, and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.