Description

Thalidomide-Nh-Peg2-C2-Nh2 Hydrochloride is a high-purity synthetic intermediate designed for advanced pharmaceutical research and development. This compound is critical for constructing antibody-drug conjugates (ADCs) and other targeted therapeutics, offering a precise chemical handle for bioconjugation. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the development of novel cancer treatments and immunomodulatory agents.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a key building block for attaching cytotoxic drugs to monoclonal antibodies via cleavable or non-cleavable linkers.
• Targeted Cancer Therapy Development: Used in the research and production of next-generation oncology drugs that selectively deliver therapeutic agents to tumor cells.
• PROTAC® (Proteolysis Targeting Chimera) Molecule Construction: Acts as a component in the design of bifunctional molecules that induce targeted protein degradation.
• Bioconjugation and Protein Labeling: Provides a reactive amine group for coupling with various biomolecules, peptides, or fluorescent dyes.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) with specific targeting moieties.
• Preclinical and Clinical Research: Supports drug discovery pipelines in academic and industrial settings for evaluating new therapeutic modalities.

Basic Information

Product Name	Thalidomide-Nh-Peg2-C2-Nh2 Hydrochloride
CAS No.	2245697-87-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thalidomide-PEG2-C2-amine HCl; 2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl Thalidomide Hydrochloride; Thalidomide-PEG2-C2-NH2•HCl; Thalidomide-O-PEG2-C2-NH2 Hydrochloride; Thalidomide amino-PEG2-C2-amide HCl; N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
EINECS	Contact for details

Quality Control

Our Thalidomide-Nh-Peg2-C2-Nh2 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (cold chain recommended for long-term stability). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain purity and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.