Description

Phenol, 3,4-Difluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex fluorinated aromatic scaffolds. It is primarily utilized by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct fluorinated aromatic cores for novel herbicides, fungicides, and pesticides with enhanced efficacy and environmental profile.
• Material Science Research: Building block for creating fluorinated polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to attach complex aryl groups under mild, palladium-catalyzed conditions.
• Chemical Biology Probes: Used in the development of fluorinated probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules at various scales.

Basic Information

Product Name	Phenol, 3,4-Difluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2244893-49-8
Molecular Formula	C₁₂H₁₅BF₂O₃
Molecular Weight	256.06 g/mol
Synonyms	3,4-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-difluorophenol; 2-(3,4-Difluoro-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,4-Difluoro-5-hydroxybenzeneboronic acid pinacol ester; Difluorophenol boronic ester; Arylboronic ester pinacol; Suzuki coupling reagent.
EINECS	Contact for details

Quality Control

Every batch of our Phenol, 3,4-Difluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive cross-coupling applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.