Description

(4E)-Tco-Peg4-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a strained trans-cyclooctene (TCO) group and a primary amine. This compound is specifically engineered for bioorthogonal click chemistry, enabling rapid, selective, and catalyst-free conjugation under mild physiological conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, facilitating the precise labeling and modification of biomolecules, nanoparticles, and drug delivery systems.

Application

• Bioorthogonal Labeling and Imaging: Conjugation of fluorescent dyes, MRI contrast agents, or other probes to antibodies, proteins, or live cells via inverse electron-demand Diels-Alder (IEDDA) reaction with tetrazines.
• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies to create stable and homogeneous ADC candidates.
• PEGylation and Bioconjugation: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic peptides, proteins, and small molecules.
• Surface Functionalization: Modification of nanoparticles, quantum dots, or solid supports for creating targeted diagnostic and therapeutic platforms.
• Chemical Biology Tool Development: Synthesis of activity-based probes and other chemical tools for studying biological processes in real-time.
• Hydrogel and Biomaterial Crosslinking: Fabrication of smart biomaterials with tunable properties for tissue engineering and controlled release applications.

Basic Information

Product Name	(4E)-Tco-Peg4-Amine
CAS No.	2243569-24-4
Molecular Formula	C27H51N3O8
Molecular Weight	545.71 g/mol
Synonyms	(4E)-trans-Cyclooct-4-en-1-yl 2,5,8,11-Tetraoxatetradecan-14-amine; TCO-PEG4-Amine; TCO-PEG4-NH2; trans-Cyclooctene-PEG4-Amine; (4E)-TCO-PEG4-NH2; 2,5,8,11-Tetraoxatetradecan-14-amine, (4E)-trans-cyclooct-4-en-1-yl-; TCO-PEG4-Amine (4E isomer); Heterobifunctional PEG linker TCO-PEG4-Amine
EINECS	Contact for details

Quality Control

Our (4E)-Tco-Peg4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.