Description

Tco-Peg3-Tco is a heterobifunctional polyethylene glycol (PEG) linker featuring a TCO (trans-cyclooctene) group at each terminus. This compound is specifically engineered for bioorthogonal click chemistry applications, enabling rapid and selective conjugation under mild, physiological conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced material science, where precise and stable cross-linking is required.

Application

• Bioorthogonal conjugation in antibody-drug conjugate (ADC) development and optimization.
• Cross-linking agent for the site-specific modification of proteins, peptides, and oligonucleotides.
• Building block for synthesizing functionalized hydrogels and biomaterials with controlled properties.
• Tool compound in chemical biology for studying biomolecular interactions and cellular processes.
• Linker for surface functionalization in diagnostic assay and biosensor development.
• Intermediate in the synthesis of complex, multi-functional polymer-drug conjugates.

Basic Information

Product Name	Tco-Peg3-Tco
CAS No.	2243569-22-2
Molecular Formula	C₂₆H₄₄N₂O₆
Molecular Weight	480.64 g/mol
Synonyms	1,11-Bis((E)-cyclooct-4-en-1-yloxy)-3,6,9-trioxaundecane; TCO-PEG3-TCO; TCO-PEG(3)-TCO; trans-Cyclooctene-PEG3-trans-Cyclooctene; Bis-TCO-PEG3; Bifunctional TCO-PEG3 Linker; TCO-PEG(3)-TCO Crosslinker; TCO-PEG3-TCO Reagent
EINECS	Contact for details

Quality Control

Our Tco-Peg3-Tco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.