Description

[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide CAS NO 2241598-34-3 is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals with superior purity and efficacy. This advanced ligand is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A highly effective ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in API synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including those for cardiovascular, central nervous system (CNS), and antiviral therapies.
• Agrochemical Active Ingredient Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and insecticides for enhanced activity and environmental profile.
• Cross-Coupling Reactions: Can be employed as a chiral auxiliary or ligand in palladium-catalyzed cross-couplings (e.g., Suzuki, Heck) to create asymmetric biaryl structures.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Enables the development of more efficient, scalable, and cost-effective manufacturing routes for chiral compounds.

Basic Information

Product Name	[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2241598-34-3
Molecular Formula	C41H64NO2PS
Molecular Weight	666.0 g/mol
Synonyms	(S)-tert-Butanesulfinamide Derivative; Chiral Sulfinamide-Phosphine Ligand; (S(R),S)-Sulfinamide Phosphine Ligand; (S)-N-((S)-(3,5-Di-tert-butyl-4-methoxyphenyl)(2-(dicyclohexylphosphino)phenyl)methyl)-2-methylpropane-2-sulfinamide; Asymmetric Hydrogenation Ligand; Dicyclohexylphosphino-Sulfinamide Hybrid Ligand; tert-Butylsulfinamide-Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and analyzed under strict quality management protocols to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and key spectroscopic data (NMR, HPLC). Our quality systems are designed to support cGMP and ISO standards for traceability, making this material suitable for use in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated place, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.