Description

[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]-1-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in modern asymmetric synthesis. Its primary value lies in enabling highly enantioselective transition metal-catalyzed reactions, which are essential for producing single-enantiomer intermediates in pharmaceutical and agrochemical research. This compound is specifically needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced materials sectors for constructing complex chiral molecules with high precision.

Application

• Asymmetric Hydrogenation Catalysis: As a key ligand for rhodium, iridium, or ruthenium complexes in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: For the production of single-enantiomer active pharmaceutical ingredients (APIs) and advanced chiral intermediates.
• Asymmetric C-C Bond Formation: Facilitating enantioselective cross-coupling, allylic substitution, and conjugate addition reactions.
• Agrochemical Research: In the development of chiral herbicides, fungicides, and plant growth regulators.
• Methodology Development: Used in academic and industrial research labs to develop new catalytic asymmetric transformations.
• Ligand Screening Libraries: As a high-value component in catalyst screening kits for discovering new reaction pathways.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]-1-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2241598-33-2
Molecular Formula	C34H44NOPS
Molecular Weight	545.75 g/mol
Synonyms	(SR)-N-[(S)-[2-(Dicyclohexylphosphino)phenyl](1-naphthyl)methyl]-N,2-dimethylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (SR,S)-N-[2-(Dicyclohexylphosphino)benzyl-(1-naphthyl)]-N,2-dimethyl-2-propanesulfinamide; Asymmetric Phosphine-Sulfinamide Ligand; Dicyclohexylphosphino-Sulfinamide Hybrid Ligand; (SR,S)-Ligand for Asymmetric Hydrogenation; CAS 2241598-33-2
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by NMR, HPLC, and chiral analysis to confirm structural identity, high chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool environment to maintain stability and prevent oxidation or degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.