Description

S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4 Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, crucial for enabling highly selective and efficient asymmetric catalytic transformations. Its unique structure, featuring both a sterically hindered sulfinamide and a bulky dicyclohexylphosphino group, makes it an indispensable tool for chemists developing novel pharmaceutical intermediates and fine chemicals. This compound is primarily sought after by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors where precise stereochemical control is paramount.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the catalytic synthesis of chiral building blocks for active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Facilitates palladium-catalyzed asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds.
• Agrochemical Synthesis: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric catalysis and organometallic chemistry.
• Fine Chemical Production: Applied in the manufacture of specialty chemicals requiring high enantiomeric excess (ee).

Basic Information

Item	Details
Product Name	S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4 Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2241598-31-0
Molecular Formula	C38H58NO2PS
Molecular Weight	623.91 g/mol
Synonyms	(SR)-N-[(S)-[3,5-Di-tert-butyl-4-methoxyphenyl][2-(dicyclohexylphosphino)phenyl]methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type Sulfinamide Ligand; Asymmetric Hydrogenation Ligand; tert-Butanesulfinamide-Dicyclohexylphosphine Hybrid Ligand; (SR,S)-N-((3,5-Di-tert-butyl-4-methoxyphenyl)(2-(dicyclohexylphosphino)phenyl)methyl)-2-methylpropane-2-sulfinamide; CAS 2241598-31-0
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric integrity. We provide comprehensive Certificates of Analysis (COA) detailing results from HPLC, NMR, and chiral analysis. Our quality management system is designed to support cGMP-compliant applications in pharmaceutical development, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.