Description

1,3-Benzenedicarboxamide, 5-[[2-(Acetyloxy)Acetyl](2-Hydroxyethyl)Amino]-N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo- is a high-purity, non-ionic iodinated contrast agent intermediate designed for advanced pharmaceutical synthesis. This compound is critical for the development of next-generation X-ray and computed tomography (CT) contrast media, offering enhanced solubility and pharmacokinetic profiles. It is primarily required by manufacturers in the diagnostic imaging, pharmaceutical, and fine chemical sectors for producing safer and more effective contrast formulations.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing non-ionic, low-osmolar iodinated contrast agents used in medical imaging.
• Diagnostic Imaging: Production of active pharmaceutical ingredients (APIs) for intravenous X-ray and CT scan contrast media.
• Contrast Media Formulation: Used in the development of aqueous injectable solutions with improved patient tolerance and renal safety profiles.
• Research & Development: Serves as a critical reference standard and starting material in radiopharmaceutical and diagnostic agent R&D.
• Fine Chemical Synthesis: Intermediate for creating specialized triiodobenzene derivatives with tailored hydrophilicity and binding characteristics.

Basic Information

Product Name	1,3-Benzenedicarboxamide, 5-[[2-(Acetyloxy)Acetyl](2-Hydroxyethyl)Amino]-N1,N3-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-
CAS No.	2232891-06-2
Molecular Formula	C21H27I3N3O9
Molecular Weight	879.07 g/mol
Synonyms	5-[[2-(Acetyloxy)acetyl](2-hydroxyethyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iodinated Contrast Agent Intermediate; Non-ionic Triiodobenzene Derivative; Iohexol/Iopamidol Related Intermediate; CT Contrast Media Precursor; 2,4,6-Triiodo-5-[(2-hydroxyethyl)[2-(acetyloxy)acetyl]amino]-N1,N3-bis(2,3-dihydroxypropyl)-1,3-benzenedicarboxamide
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict pharmaceutical-grade standards. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting requirements for contrast media API synthesis. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided and can be tailored to meet specific customer or regulatory (e.g., ICH Q3) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.