Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(1-Methylcyclobutyl)Propanoic Acid is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound matters as a critical building block for introducing sterically hindered, conformationally constrained side chains into peptide backbones, enabling the development of novel bioactive molecules with enhanced stability and specificity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for creating next-generation peptide therapeutics, enzyme inhibitors, and other high-value chemical entities.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Conformational Studies: To introduce the unique 1-methylcyclobutyl side chain, which imposes specific torsional angles and restricts backbone flexibility in peptide mimetics.
• Medicinal Chemistry: A key intermediate in the research and development of novel drug candidates targeting GPCRs, proteases, and other protein-protein interactions.
• Peptidomimetic Design: For creating metabolically stable analogs of natural peptides with improved pharmacokinetic properties.
• Chemical Biology Probes: Incorporation into peptides used as tools to study enzyme mechanisms or cellular pathways.
• Agrochemical Research: Potential use in the synthesis of peptide-based bioactive agents for crop protection.

Basic Information

Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(1-Methylcyclobutyl)Propanoic Acid
CAS No.	2231664-19-8
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	Fmoc-(R)-1-Methylcyclobutylalanine; Fmoc-(R)-1-Me-Cba-OH; (2R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-methylcyclobutyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-methylcyclobutyl-D-alanine; Fmoc-D-1-methylcyclobutylalanine; Fmoc-D-Cba(1-Me)-OH; Fmoc-D-(1-methylcyclobutyl)Ala-OH; N-α-Fmoc-D-1-methylcyclobutylalanine
EINECS	Contact for details

Quality Control

Our (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(1-Methylcyclobutyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.