Description

tert-Butyl (4-Ethynyl-2-Methylphenyl)Carbamate is a specialized organic building block featuring both a carbamate protecting group and a terminal alkyne functional group. This compound is of significant value in pharmaceutical research and fine chemical synthesis, where it serves as a key intermediate for constructing more complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop novel drug-like molecules.
• Peptide Mimetics & PROTACs: The alkyne group enables click chemistry for the modular assembly of peptide derivatives and proteolysis-targeting chimeras (PROTACs).
• Agrochemical Synthesis: Serves as an intermediate in the development of new herbicides and fungicides with enhanced efficacy.
• Material Science: Employed in the synthesis of functionalized polymers and dendrimers with tailored properties.
• Cross-Coupling Reactions: The terminal alkyne acts as a versatile handle for Sonogashira, Glaser, and other metal-catalyzed coupling reactions.

Basic Information

Product Name	tert-Butyl (4-Ethynyl-2-Methylphenyl)Carbamate
CAS No.	2229235-51-0
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	4-Ethynyl-2-methylphenyl carbamic acid tert-butyl ester; tert-Butyl N-(4-ethynyl-2-methylphenyl)carbamate; Boc-4-ethynyl-2-methylaniline; N-Boc-4-ethynyl-2-methylaniline; 2-Methyl-4-ethynylphenyl tert-butylcarbamate; Carbamic acid, N-(4-ethynyl-2-methylphenyl)-, 1,1-dimethylethyl ester; 4-Ethynyl-2-methylaniline N-Boc derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-Ethynyl-2-Methylphenyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.