Description

Azadibenzocyclooctyne-Peg1-n-Hydroxysuccinimidyl Ester is a highly reactive, heterobifunctional crosslinking agent designed for bioorthogonal conjugation chemistry. Its core value lies in enabling efficient, catalyst-free, and selective labeling of biomolecules under physiological conditions, which is critical for advanced research and development. This compound is essential for scientists and manufacturers in the fields of bioconjugation, proteomics, antibody-drug conjugate (ADC) development, and in vivo imaging, where precise and stable linkage of molecules is required.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: For site-specific conjugation of cytotoxic payloads to monoclonal antibodies via amine groups.
• Biomolecule Labeling and Tagging: Functionalization of proteins, peptides, and oligonucleotides with fluorophores, biotin, or other probes for detection and analysis.
• Surface Modification: Immobilization of biomolecules onto nanoparticles, biosensors, or microarray slides to create functionalized surfaces.
• In Vivo and In Vitro Imaging: Conjugation of imaging agents (e.g., near-infrared dyes) for targeted bioimaging applications.
• Chemical Biology and Proteomics: As a key reagent for click chemistry-based strategies to study protein function, interactions, and localization.
• Polymer and Material Science: Synthesis of functionalized PEG-based polymers and hydrogels for biomedical applications.

Basic Information

Product Name	Azadibenzocyclooctyne-Peg1-n-Hydroxysuccinimidyl Ester
CAS No.	2228857-34-7
Molecular Formula	C26H23N3O5
Molecular Weight	457.48 g/mol
Synonyms	ADIBO-PEG1-NHS Ester; DBCO-PEG1-NHS Ester; Azadibenzocyclooctyne-PEG1-NHS; 1-(3-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxy)-3-oxopropyl)-1H-pyrrole-2,5-dione; Dibenzocyclooctyne-PEG1-N-hydroxysuccinimide ester; NHS-PEG1-DBCO; DBCO-PEG1-Succinimidyl Ester; 3-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxy)-3-oxopropyl 2,5-dioxopyrrolidin-1-yl carbonate
EINECS	Contact for details

Quality Control

Our Azadibenzocyclooctyne-Peg1-n-Hydroxysuccinimidyl Ester is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.