Description

2,2-Difluoro-1-(4-Fluorophenyl)Cyclopropane-1-Carboxylic Acid is a high-value, multi-fluorinated cyclopropane carboxylic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its unique difluorocyclopropane scaffold, combined with the fluorinated aromatic ring, makes it a key building block for introducing conformational rigidity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorocyclopropane moiety can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a specialized monomer or additive in the synthesis of advanced polymers and functional materials with tailored properties.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring the effects of fluorination and strained ring systems on chemical and physical properties.
• Ligand and Catalyst Development: Potential building block for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2,2-Difluoro-1-(4-Fluorophenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	2228382-27-0
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	1-(4-Fluorophenyl)-2,2-difluorocyclopropane-1-carboxylic acid; 2,2-Difluoro-1-(p-fluorophenyl)cyclopropanecarboxylic acid; 4-Fluoro-α-(2,2-difluorocyclopropyl)benzoic acid; DFPC Acid; (4-Fluorophenyl)-2,2-difluorocyclopropanecarboxylic acid; 2228382-27-0; 1-(4-Fluorophenyl)-2,2-difluorocyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1-(4-Fluorophenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.