Description

4-Bromo-2-Ethynyl-1-Methylbenzene is a high-purity, multi-functional aromatic building block featuring both bromo and ethynyl substituents. This compound is valued for its versatility in advanced organic synthesis, enabling efficient cross-coupling and cycloaddition reactions to construct complex molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: Enables Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to introduce complex aryl-alkyne functionalities.
• Chemical Biology Probes: Utilized in click chemistry (e.g., CuAAC) for bioconjugation and labeling of biomolecules for diagnostic and research applications.

Basic Information

Product Name	4-Bromo-2-Ethynyl-1-Methylbenzene
CAS No.	2228330-14-9
Molecular Formula	C9H7Br
Molecular Weight	195.06 g/mol
Synonyms	1-Bromo-4-ethynyl-3-methylbenzene; 2-Ethynyl-4-bromotoluene; 4-Bromo-2-ethynyltoluene; 3-Methyl-4-bromophenylacetylene; 4-Bromo-3-methylphenylacetylene; (4-Bromo-3-methylphenyl)ethyne
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Ethynyl-1-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive research and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.