Description

5-((3As,4S,6Ar)-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-Yl)-n-(2-(2-(Prop-2-Yn-1-Yloxy)Ethoxy)Ethyl)Pentanamide is a sophisticated synthetic intermediate featuring a biotin-derived core modified with a propargyl-PEG linker. This compound matters for its role as a key building block in the development of biotinylated probes and targeted drug conjugates, enabling precise bioconjugation via click chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in chemical biology, proteomics, and the development of novel therapeutics and diagnostic agents.

Application

• Chemical Biology Probe Synthesis: Acts as a versatile precursor for creating biotin-tagged molecules for target identification and pull-down assays.
• ADC (Antibody-Drug Conjugate) Development: Serves as a linker-payload intermediate for constructing targeted cancer therapies.
• Proteomics Research: Used to synthesize affinity tags for the enrichment and study of proteins and protein complexes.
• Diagnostic Reagent Manufacturing: Employed in the production of labeled compounds for in vitro diagnostic kits and imaging agents.
• Bioconjugation & Click Chemistry: The terminal alkyne group facilitates efficient, site-specific conjugation to azide-functionalized biomolecules.
• Academic & Pharmaceutical R&D: A critical reagent for exploratory research in medicinal chemistry and molecular recognition.

Basic Information

Product Name	5-((3As,4S,6Ar)-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-Yl)-n-(2-(2-(Prop-2-Yn-1-Yloxy)Ethoxy)Ethyl)Pentanamide
CAS No.	2227450-68-0
Molecular Formula	C19H30N4O4S
Molecular Weight	410.53 g/mol
Synonyms	Biotin-PEG2-Alkyne; Biotin-PEG2-Propargyl; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl]pentanamide; Biotin-PEG2-Alkyne; Biotinylated PEG Alkyne; Alkyne-PEG2-Biotin; Biotin Alkyne PEG2; Biotin-PEG2-C≡CH
EINECS	Contact for details

Quality Control

Our 5-((3As,4S,6Ar)-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-Yl)-n-(2-(2-(Prop-2-Yn-1-Yloxy)Ethoxy)Ethyl)Pentanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.