Description

Exo-8-Oxabicyclo[3.2.1]octane-3-carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic ether structure with a nitrile functional group. This compound is of significant value for its role as a sophisticated building block in the synthesis of complex, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries via further functionalization of the nitrile group and the strained bicyclic framework.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for target molecules.
• Agrochemical Synthesis: Potential application as a building block for developing new crop protection agents with unique modes of action.
• Material Science Research: Investigated for the preparation of specialty polymers or ligands due to its rigid, oxygen-containing bicyclic structure.

Basic Information

Product Name	Exo-8-Oxabicyclo[3.2.1]octane-3-carbonitrile
CAS No.	2227197-28-4
Molecular Formula	C8H9NO
Molecular Weight	135.16 g/mol
Synonyms	8-Oxabicyclo[3.2.1]octane-3-carbonitrile, exo-; (1R,5S)-8-Oxabicyclo[3.2.1]octane-3-carbonitrile; exo-3-Cyano-8-oxabicyclo[3.2.1]octane; Bicyclo[3.2.1]octane-3-carbonitrile, 8-oxa-, (1R,5S)-rel-; 2227197-28-4; 8-Oxabicyclo[3.2.1]octane-3-carbonitrile (exo-)
EINECS	Contact for details

Quality Control

Our Exo-8-Oxabicyclo[3.2.1]octane-3-carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (exo- isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.