Description

2-Propanesulfinamide, n-[4-Chloro-1-(2,5-Difluorophenyl)Butylidene]-2-Methyl-, [S(S)]- is a high-value, chiral sulfinamide building block with the CAS number 2227089-41-8. This compound is specifically designed for the synthesis of complex, stereochemically defined molecules, offering researchers and process chemists a critical tool for constructing challenging molecular architectures. It is primarily utilized in advanced pharmaceutical research and development, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates where precise stereocontrol is paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Serves as a versatile chiral auxiliary or reagent for inducing stereoselectivity in carbon-nitrogen and carbon-sulfur bond-forming reactions.
• API Development: Used in the research-scale and pilot-scale production of Active Pharmaceutical Ingredients (APIs) requiring specific (S,S) stereochemistry.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing access to enantiomerically pure analogs in drug discovery programs.
• Process Chemistry Optimization: Employed in route scouting and scaling studies for more efficient and cost-effective synthetic pathways to target molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) specializing in complex, chiral molecules.

Basic Information

Product Name	2-Propanesulfinamide, n-[4-Chloro-1-(2,5-Difluorophenyl)Butylidene]-2-Methyl-, [S(S)]-
CAS No.	2227089-41-8
Molecular Formula	C14H17ClF2NOS
Molecular Weight	328.81 g/mol
Synonyms	(S,S)-N-[(4-Chloro-1-(2,5-difluorophenyl)butylidene]-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide derivative; (S,S)-2-Methyl-N-((S)-4-chloro-1-(2,5-difluorophenyl)butylidene)propane-2-sulfinamide; Chiral Sulfinamide Intermediate; tert-Butylsulfinyl Imine Derivative; (S)-2-Methyl-2-propanesulfinamide, N-[(4-chloro-1-(2,5-difluorophenyl)butylidene]-, (S)-; (S,S)-Sulfinamide Building Block
EINECS	Contact for details

Quality Control

Every batch of our 2-Propanesulfinamide, n-[4-Chloro-1-(2,5-Difluorophenyl)Butylidene]-2-Methyl-, [S(S)]- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the identity, purity, and enantiomeric excess meet the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing specifications such as chiral purity (HPLC), assay, and impurity profiles are available for each lot and provided upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.