Description

1-(3-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation, which is critical for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that require the incorporation of the trifluoromethylphenyl-pyrazole scaffold.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents due to its reactive boronic acid group.
• Ligand Synthesis for Catalysis: Used to construct sophisticated pyrazole-based ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	1-(3-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid
CAS No.	2225178-71-0
Molecular Formula	C10H8BF3N2O2
Molecular Weight	256.00 g/mol
Synonyms	[4-(3-Trifluoromethylphenyl)-1H-pyrazol-1-yl]boronic acid; 1H-Pyrazole-4-boronic acid, 1-[3-(trifluoromethyl)phenyl]-; 1-(3-(Trifluoromethyl)phenyl)-1H-pyrazole-4-boronic acid; 4-Borono-1-(3-trifluoromethylphenyl)pyrazole; 1-(α,α,α-Trifluoro-m-tolyl)-1H-pyrazole-4-boronic acid; 1-(m-Trifluoromethylphenyl)pyrazole-4-boronic acid; 3-Trifluoromethylphenyl pyrazole boronic acid
EINECS	Contact for details

Quality Control

Our 1-(3-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.