Description

1-(4-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing novel active ingredients and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those containing trifluoromethyl and pyrazole motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura palladium-catalyzed cross-couplings to form biaryl and heterobiaryl bonds.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Item	Details
Product Name	1-(4-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid
CAS No.	2225170-71-6
Molecular Formula	C10H6BF3N2O2
Molecular Weight	254.98 g/mol
Synonyms	4-(4-(Trifluoromethyl)phenyl)-1H-pyrazole-1-boronic acid; [1-(4-Trifluoromethylphenyl)-1H-pyrazol-4-yl]boronic acid; 1H-Pyrazole-4-boronic acid, 1-[4-(trifluoromethyl)phenyl]-; 4-Borono-1-(4-trifluoromethylphenyl)pyrazole; (1-(4-(Trifluoromethyl)phenyl)-1H-pyrazol-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Trifluoromethylphenyl)-1H-Pyrazole-4-Boronic Acid is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We provide comprehensive analytical data, including HPLC purity, NMR, and MS confirmation. A Certificate of Analysis (COA) is available for each lot, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.