Description

3-Chloro-4-Bromo-6-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex, multi-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where specific halogenated aromatic systems are required for bioactivity.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a model substrate for testing new catalytic systems in cross-coupling chemistry.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-directed synthetic projects.

Basic Information

Product Name	3-Chloro-4-Bromo-6-Methylphenylboronic Acid Pinacol Ester
CAS No.	2223046-57-7
Molecular Formula	C13H17BBrClO2
Molecular Weight	334.44 g/mol
Synonyms	(3-Chloro-4-bromo-6-methylphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-bromo-6-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-bromo-6-methylbenzeneboronic acid pinacol ester; Boronic acid, B-(3-chloro-4-bromo-6-methylphenyl)-, 1,1-dimethylethyl ester (9CI); Pinacol (3-chloro-4-bromo-6-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Bromo-6-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC/NMR). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can support regulatory filings with necessary documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (THF, DCM, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.