Description

2-Fluoro-6-Bromopyridine-4-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated and brominated pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and other functionalized polymers.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronic ester group acts as a stable, reactive handle for forming carbon-carbon bonds with a wide variety of aryl and heteroaryl halides.
• Chemical Biology & Medicinal Chemistry: Employed in the design and synthesis of molecular probes, bio-conjugates, and tool compounds for target validation and mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	2-Fluoro-6-Bromopyridine-4-Boronic Acid Pinacol Ester
CAS No.	2223035-36-5
Molecular Formula	C11H12BBrFNO2
Molecular Weight	300.94 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(6-bromo-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-(6-Bromo-2-fluoro-4-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (6-Bromo-2-fluoropyridin-4-yl)boronic acid pinacol ester; 2-Fluoro-6-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Fluoro-6-bromopyridine-4-boronic acid, pinacol ester; B-(6-Bromo-2-fluoropyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2223035-36-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Bromopyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature: 2-8°C for prolonged periods; allow to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.