Description

[S(R)]-n-[(R)-[2-(Diphenylphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. This compound matters because it enables highly enantioselective transition metal-catalyzed reactions, which are fundamental for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. Pharmaceutical R&D laboratories and advanced fine chemical manufacturers need this high-value ligand to develop novel synthetic routes and improve the efficiency and selectivity of key bond-forming steps.

Application

• Asymmetric Catalysis: As a privileged ligand for palladium, rhodium, and iridium complexes in enantioselective hydrogenation, cross-coupling, and allylic substitution reactions.
• Pharmaceutical Intermediate Synthesis: For the stereocontrolled construction of chiral centers in the development of novel drug candidates, including kinase inhibitors and antiviral agents.
• Methodology Development: A key reagent in academic and industrial research for discovering new catalytic asymmetric transformations.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides and pesticides where biological activity is stereospecific.
• Chiral Auxiliary: Can function as a chiral directing group or resolving agent in diastereoselective synthesis due to its robust sulfinamide moiety.

Basic Information

Item	Details
Product Name	[S(R)]-n-[(R)-[2-(Diphenylphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2222798-18-5
Molecular Formula	C30H32NOPS
Molecular Weight	485.62 g/mol
Synonyms	(R)-N-[(R)-[2-(Diphenylphosphino)phenyl](phenyl)methyl]-2-methylpropane-2-sulfinamide; (R)-N-((R)-(2-(Diphenylphosphino)phenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Hybrid P,N-Ligand; (R,R)-Sulfinamide Phosphine Ligand; tert-Butanesulfinamide-based phosphine ligand; CAS 2222798-18-5
EINECS	Contact for details

Quality Control

Our production of this high-purity ligand adheres to stringent quality protocols. Every batch is characterized by NMR (1H, 13C, 31P), HPLC, and optical rotation analysis to confirm structural integrity, high chemical purity (typically >97%), and correct enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.