Description

Nintedanib-013-Co CAS NO 2218446-42-3 is a high-purity chemical intermediate designed for advanced pharmaceutical research and development. This compound is critical for the synthesis of targeted therapeutic agents, offering researchers a reliable building block for complex molecular structures. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel drug candidates, particularly in the oncology and fibrosis research sectors.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of active pharmaceutical ingredients (APIs).
• Oncology Research: Used in the R&D of small-molecule inhibitors targeting specific kinase pathways.
• Preclinical Development: Serves as a critical reference standard or impurity standard in analytical method development and validation.
• Process Chemistry: Employed in route scouting and optimization for scalable API manufacturing processes.
• Academic Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials under GMP conditions.

Basic Information

Product Name	Nintedanib-013-Co
CAS No.	2218446-42-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nintedanib Impurity 13-Co; Nintedanib Related Compound 13-Co; 2218446-42-3; Nintedanib-013-Co; Nintedanib Co-impurity 13; BIBF 1120 Impurity 13-Co; OFEV Impurity 13-Co; Vargatef Impurity 13-Co
EINECS	Contact for details

Quality Control

Our Nintedanib-013-Co is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and quality assurance requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.