Description

(3S,3'S)-3,3'-Bis(tert-Butyl)-2,2',3,3'-Tetrahydro-4,4'-Bi-1,3-Benzoxaphosphole CAS NO 2207601-04-3 is a high-purity, chiral bisphosphine ligand characterized by its unique sterically hindered, electron-rich structure. This compound is a critical catalyst component in asymmetric synthesis, enabling the production of enantiomerically pure intermediates for pharmaceuticals and fine chemicals. It is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high selectivity and yield in transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Cross-Coupling Catalysis: Employed in Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to construct complex molecular architectures.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers with high enantiomeric excess in fine chemical production.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drugs, including antivirals, oncology treatments, and cardiovascular agents.
• Agrochemical Research: Applied in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor or ligand in the development of chiral polymers and advanced catalytic materials.
• Academic & Process R&D: A valuable tool for methodology development and exploring new asymmetric transformations in academic and industrial laboratories.

Basic Information

Product Name	(3S,3'S)-3,3'-Bis(tert-Butyl)-2,2',3,3'-Tetrahydro-4,4'-Bi-1,3-Benzoxaphosphole
CAS No.	2207601-04-3
Molecular Formula	C28H38O2P2
Molecular Weight	476.53 g/mol
Synonyms	(S,S)-3,3'-Di-tert-butyl-2,2',3,3'-tetrahydro-4,4'-bi-1,3-benzoxaphosphole; (S,S)-DTB-BOXAPHOS; (3S,3'S)-DTB-BOXAPHOS; Chiral DTB-BOXAPHOS ligand; Bis(tert-butyl)benzoxaphosphole ligand; (S,S)-Bisphosphine ligand; Asymmetric bisphosphine; (S,S)-3,3'-Di-t-butyl-2,2',3,3'-tetrahydro-4,4'-bi-1,3-benzoxaphosphole
EINECS	Contact for details

Quality Control

Every batch of (3S,3'S)-3,3'-Bis(tert-Butyl)-2,2',3,3'-Tetrahydro-4,4'-Bi-1,3-Benzoxaphosphole is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for chiral purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and full analytical data (including NMR, HPLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.