Description

Hydroxy o-Desmethyl Apixaban Sulfate is a key pharmaceutical intermediate and reference standard in the synthesis of active pharmaceutical ingredients (APIs). This high-purity compound is critical for ensuring the quality, safety, and efficacy of final drug products in anticoagulant therapy. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in the development, production, and quality control of novel therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Apixaban and related anticoagulant APIs.
• Reference Standard: Used for analytical method development, validation, and quality control testing (e.g., HPLC, LC-MS) to ensure batch-to-batch consistency.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying process-related impurities and degradation products in drug substances.
• Research & Development: Essential for pharmacokinetic, metabolic, and stability studies in preclinical and clinical research phases.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing characterized materials for stability and impurity profiling.
• Custom Synthesis: A starting material for the development of novel analogs and derivatives in medicinal chemistry programs.

Basic Information

Product Name	Hydroxy o-Desmethyl Apixaban Sulfate
CAS No.	2203515-00-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid sulfate; Apixaban Impurity; Apixaban Related Compound; Apixaban Sulfate Derivative; O-Desmethyl Hydroxy Apixaban Sulfate; 1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-, sulfate (1:1)
EINECS	Contact for details

Quality Control

Our Hydroxy o-Desmethyl Apixaban Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.