Description

Metronidazole-Hydroxy D2 is a deuterated derivative of the well-known nitroimidazole antibiotic, Metronidazole. This compound is specifically designed for use as a high-quality internal standard in analytical chemistry, offering superior precision for quantitative analysis and metabolic studies. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring accurate and reliable measurement of Metronidazole and its metabolites.

Application

• Analytical Reference Standard: Primary use as an internal standard for the precise quantification of Metronidazole via LC-MS/MS, GC-MS, and HPLC methods.
• Pharmaceutical Research & Development: Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies, enabling accurate tracking of drug metabolism and distribution.
• Clinical Toxicology: Used in assays to monitor Metronidazole levels in patient plasma or serum for therapeutic drug monitoring (TDM) or overdose cases.
• Metabolite Identification: Aids in the identification and structural elucidation of Metronidazole metabolites in biological matrices.
• Method Development & Validation: Serves as a stable, isotopically-labeled compound for developing and validating robust bioanalytical methods.
• Quality Control in Manufacturing: Employed in the QC laboratories of API manufacturers to ensure batch consistency and purity of Metronidazole products.

Basic Information

Product Name	Metronidazole-Hydroxy D2
CAS No.	2196180-19-3
Molecular Formula	C₆H₈D₂N₃O₃
Molecular Weight	174.17 g/mol (approx.)
Synonyms	2-Methyl-5-nitro-1H-imidazole-1-ethanol-d2 (hydroxy); Metronidazole D2 (Hydroxy Labeled); Metronidazole (hydroxy-d2); Deuterated Metronidazole; Metronidazole-d2; [D2]-Metronidazole; 1-(2-Hydroxyethyl-d2)-2-methyl-5-nitroimidazole; Internal Standard for Metronidazole.
EINECS	Contact for details

Quality Control

Every batch of Metronidazole-Hydroxy D2 is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as isotopic purity (D-enrichment), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures the material meets the exacting standards required for reliable analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle with appropriate laboratory precautions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.