Description

Lenalidomide-Peg1-Azide is a high-purity, bifunctional chemical linker designed for advanced pharmaceutical research and development. This compound is critical for creating antibody-drug conjugates (ADCs) and other targeted therapeutics by enabling precise, site-specific bioconjugation. It is an essential reagent for R&D scientists and process development teams in the pharmaceutical and biotech industries focused on oncology and immunology.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker-payload intermediate for constructing novel ADCs with controlled drug-to-antibody ratios (DAR).
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Used in the modular assembly of heterobifunctional molecules for targeted protein degradation.
• Bioconjugation and Labeling: Enables the site-specific attachment of fluorophores, drugs, or other payloads to proteins, antibodies, or peptides via click chemistry (CuAAC).
• Chemical Biology Research: A versatile tool for studying protein function, cellular pathways, and drug-target interactions through bioorthogonal labeling strategies.
• Precision Medicine Platforms: Integral to developing next-generation targeted therapies and companion diagnostics.
• Process Chemistry & Scale-Up: Supports the transition from laboratory-scale synthesis to GMP-compliant manufacturing of clinical trial materials.

Basic Information

Product Name	Lenalidomide-Peg1-Azide
CAS No.	2185795-67-7
Molecular Formula	C20H21N5O5
Molecular Weight	411.41 g/mol
Synonyms	Lenalidomide-PEG1-N3; 3-(4-Azidobutoxy)-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione; Lenalidomide-PEG1-azide; N-(4-Azidobutyl)lenalidomide; Lenalidomide Azide PEG Conjugate; Azido-PEG1-lenalidomide; Lenalidomide-PEG1-N3 Linker
EINECS	Contact for details

Quality Control

Our Lenalidomide-Peg1-Azide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 standards, and material can be supplied under GMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.