Description

Apn-C3-Peg4-Alkyne CAS NO 2183440-36-8 is a specialized bifunctional linker molecule featuring a terminal alkyne group and a protected amine, connected by a flexible tetraethylene glycol (PEG4) spacer. This compound is engineered to facilitate efficient bioconjugation and click chemistry reactions, enabling the precise labeling and modification of biomolecules. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science, where reliable, high-purity building blocks are critical for success.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: The alkyne handle enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for site-specific attachment of payloads, toxins, or fluorophores to proteins and antibodies.
• Proteomics and Biomarker Discovery: Used to create functionalized probes for labeling and enriching specific proteins or peptides from complex biological mixtures via click chemistry.
• Polymer and Materials Functionalization: Serves as a versatile monomer or cross-linker for synthesizing smart polymers, hydrogels, and surface coatings with tailored biological activity.
• Diagnostic Reagent Development: Facilitates the creation of sensitive diagnostic assays by linking detection molecules (e.g., enzymes, dyes) to targeting ligands.
• Chemical Biology Tool Development: A key intermediate for synthesizing activity-based probes (ABPs) and other chemical tools to study enzyme function and cellular pathways.
• Nanoparticle and Drug Delivery System Fabrication: Used to functionalize the surface of nanoparticles, liposomes, or other carriers for targeted delivery applications.

Basic Information

Product Name	Apn-C3-Peg4-Alkyne
CAS No.	2183440-36-8
Molecular Formula	C20H36N2O6
Molecular Weight	400.51 g/mol
Synonyms	1-Amino-3,6,9,12-tetraoxapentadec-14-yn-15-oic acid amide; Fmoc-8-amino-3,6-dioxaoctanoic acid-PEG4-alkyne; N-(3-Aminopropyl)-N'-(prop-2-yn-1-yl)-3,6,9,12-tetraoxapentadecanediamide; Alkyne-PEG4-Amine; Propargyl-PEG4-Amine; 14-Azido-3,6,9,12-tetraoxatetradecan-1-amine derivative; PEG4 Alkyne Amine; Click Chemistry Alkyne Linker
EINECS	Contact for details

Quality Control

Every batch of Apn-C3-Peg4-Alkyne is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.