Description

Methyltetrazine-Peg8-Nhs Ester is a heterobifunctional crosslinking reagent designed for advanced bioconjugation and labeling applications. This compound is critical for researchers and developers requiring precise, stable, and efficient attachment of biomolecules, such as antibodies or proteins, to various probes and surfaces. It is primarily needed by professionals in the pharmaceutical, diagnostic, and life sciences industries for developing targeted therapeutics, imaging agents, and sophisticated assay platforms.

Application

• Conjugation of biomolecules (e.g., antibodies, proteins, peptides) to fluorophores, nanoparticles, or solid supports for diagnostic assay development.
• Site-specific labeling in antibody-drug conjugate (ADC) research and development for targeted cancer therapies.
• Preparation of fluorescent probes and imaging agents for in vitro and in vivo bioimaging studies.
• Surface functionalization of biosensors and microarray chips to create specific capture surfaces.
• Crosslinking in materials science for creating bioactive hydrogels or polymer conjugates.
• Tool compound in chemical biology for studying biomolecular interactions via tetrazine ligation (inverse electron-demand Diels-Alder reaction).

Basic Information

Product Name	Methyltetrazine-Peg8-Nhs Ester
CAS No.	2183440-34-6
Molecular Formula	C41H66N6O15
Molecular Weight	883.0 g/mol (Contact for details)
Synonyms	5-Methyltetrazine-PEG8-NHS ester; Methyltetrazine-PEG8-NHS ester; 2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(2-(2-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propanoate; m-Tetrazine-PEG8-NHS ester; Methyl-Tz-PEG8-NHS; NHS-PEG8-Methyltetrazine
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Peg8-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.