Description

Dbco-Peg4-Pfp Ester is a heterobifunctional crosslinker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a pentafluorophenyl (PFP) ester for efficient amine conjugation. This compound is critical for creating stable, bioconjugate structures without the need for cytotoxic copper catalysts. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science for labeling proteins, antibodies, and nanoparticles.

Application

• Bioconjugate Synthesis: Site-specific labeling of antibodies, proteins, and peptides for diagnostic and therapeutic applications.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the stable, copper-free linkage of cytotoxic payloads to targeting antibodies.
• Fluorescent Probe & Sensor Fabrication: Conjugating fluorophores or other reporter molecules to biomolecules for imaging and detection.
• Polymer & Biomaterial Functionalization: Modifying surfaces of nanoparticles, hydrogels, and other materials with bioactive ligands.
• Click Chemistry Toolkits: A key reagent in research kits for bioorthogonal labeling and ligation studies.
• Diagnostic Reagent Preparation: Creating stable conjugates for ELISA, lateral flow assays, and other immunoassays.

Basic Information

Product Name	Dbco-Peg4-Pfp Ester
CAS No.	2182601-19-8
Molecular Formula	C37H39F5N2O8
Molecular Weight	734.72 g/mol
Synonyms	DBCO-PEG4-PFP ester; DBCO-PEG4-PFP ester; Dibenzocyclooctyne-PEG4-Pentafluorophenyl Ester; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-((2,3,5,6-tetrafluoro-4-(2,3,5,6-tetrafluorophenoxy)phenyl)amino)-1-oxo-5,8,11,14-tetraoxa-2-azapentadecan-15-oate); Azadibenzocyclooctyne-PEG4-PFP Ester; ADIBO-PEG4-PFP Ester; DBCO-PEG4-Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our Dbco-Peg4-Pfp Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.