Description

Bexarotene-D4 CAS NO 2182068-00-2 is a deuterated analog of the synthetic retinoid Bexarotene, where four hydrogen atoms are replaced with deuterium, a stable isotope. This isotopic labeling is critical for enhancing the precision and reliability of pharmacokinetic and metabolic studies, serving as an essential internal standard in quantitative mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, analytical chemists, and contract research organizations (CROs) engaged in the development and bioanalysis of retinoid-based therapies.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity, isotopically labeled internal standard for the accurate quantification of Bexarotene in biological matrices (plasma, serum, tissue) during bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Facilitates precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Stable Isotope Dilution Assays: Enables highly accurate and sensitive measurement of Bexarotene concentrations, minimizing matrix effects and improving assay reproducibility.
• Pharmaceutical Quality Control: Supports impurity profiling and assay verification in the manufacturing of Bexarotene active pharmaceutical ingredients (APIs) and finished dosage forms.
• Metabolite Identification: Aids in the structural elucidation of Bexarotene metabolites by providing a distinct mass spectrometric signature for comparison.

Basic Information

Product Name	Bexarotene-D4
CAS No.	2182068-00-2
Molecular Formula	C24H24D4O2
Molecular Weight	352.51 g/mol (approx.)
Synonyms	4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid-d4; LGD1069-d4; Targretin-d4; Bexarotene (tetradeuterated); Bexarotene-d4; [2H4]-Bexarotene
EINECS	Contact for details

Quality Control

Our Bexarotene-D4 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (by NMR or MS), chemical purity (by HPLC), and identity confirmation. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.