Description

Bis(Trifluoroacetic Acid) is a specialized fluorinated organic compound that serves as a powerful reagent and precursor in advanced chemical synthesis. Its unique structure, featuring two trifluoroacetyl groups, makes it a critical intermediate for introducing trifluoromethyl functionalities into target molecules, a key modification in modern pharmaceutical and agrochemical development. This high-value chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to enhance the metabolic stability and lipophilicity of their compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with trifluoromethyl groups, improving drug potency and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the CF3 group enhances biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Polymer and Material Science: Employed in the modification of polymer backbones to introduce fluorinated segments, altering material properties like chemical resistance, thermal stability, and surface energy.
• Organic Synthesis Reagent: Acts as a strong acylating agent and a source of the trifluoroacetyl moiety in various organic transformations, including esterifications and amide formations.
• Research & Development: A valuable tool in medicinal chemistry and chemical biology for probing structure-activity relationships and developing new chemical entities.

Basic Information

Item	Details
Product Name	Bis(Trifluoroacetic Acid)
CAS No.	2173992-45-3
Molecular Formula	C4HF6O4
Molecular Weight	218.04 g/mol
Synonyms	Hexafluorodiacetic Acid; Bis(trifluoroacetyl) Oxide; Perfluorodiacetic Acid; Trifluoroacetic Anhydride Dimer; 2,2,2-Trifluoroacetic Acid Dimer; Oxobis(2,2,2-trifluoroacetic acid); 1,1'-(Oxydicarbonyl)bis(2,2,2-trifluoroethanone)
EINECS	Contact for details

Quality Control

Our Bis(Trifluoroacetic Acid) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration, impurity profiling by GC/HPLC, and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and a strong acid/organic solvent; containers must be kept tightly sealed to exclude moisture and stored separately from bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 1.0% (total)
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.