Description

2-[(Cyanomethyl)({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]Acetic Acid CAS NO 2172570-83-9 is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in enabling the precise and efficient construction of complex peptides and peptidomimetics, which are essential for pharmaceutical research and development. This high-purity intermediate is primarily needed by research institutions, biotechnology companies, and pharmaceutical manufacturers engaged in the discovery of novel therapeutic agents, including peptide-based drugs and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated, stepwise assembly of custom peptide sequences.
• Pharmaceutical Research & Development: A crucial intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Used to introduce functional handles (via the cyano and carboxylic acid groups) for attaching fluorophores, biotin, or other probes to peptides.
• Combinatorial Chemistry Libraries: Serves as a building block for generating diverse libraries of peptide-like compounds for high-throughput screening.
• Peptidomimetic Design: Facilitates the creation of modified peptides with enhanced stability, bioavailability, or biological activity.
• Academic and Contract Research: Supports fundamental biochemical research and outsourced drug discovery programs requiring high-quality synthetic intermediates.

Basic Information

Product Name	2-[(Cyanomethyl)({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]Acetic Acid
CAS No.	2172570-83-9
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	Fmoc-N(CN-CH2)-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(cyanomethyl)glycine; N-Fmoc-N-(cyanomethyl)glycine; (Fmoc-N(CN-Me)-Gly-OH); 2-[(Cyanomethyl)(9-fluorenylmethoxycarbonyl)amino]acetic acid; Nα-Fmoc-Nα-(cyanomethyl)glycine; Fmoc-N(cyanomethyl)glycine; N-(Cyanomethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine
EINECS	Contact for details

Quality Control

Our production of 2-[(Cyanomethyl)({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]Acetic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Certificates of Analysis (COA) are provided with each shipment, detailing results from comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. We support compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled temperature between 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.