Description

Amivantamab is a bispecific monoclonal antibody designed to target and inhibit the epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (c-MET) pathways. This targeted therapeutic approach is critical for disrupting key oncogenic signaling cascades in specific cancer types. It is primarily utilized in advanced pharmaceutical research and clinical development for oncology applications, particularly in addressing resistant or refractory non-small cell lung cancer (NSCLC).

Application

• Oncological Therapeutics: Primary application in the research and development of targeted cancer therapies, specifically for EGFR exon 20 insertion-mutated non-small cell lung cancer (NSCLC).
• Clinical Trial Material (CTM): Serves as a key active pharmaceutical ingredient (API) in formulations for Phase I-III clinical trials investigating novel treatment regimens.
• Biopharmaceutical Research: Used as a reference standard or tool compound in preclinical studies to investigate mechanisms of resistance and combination therapy strategies.
• Drug Discovery & Development: Employed in bioassays and pharmacokinetic/pharmacodynamic (PK/PD) modeling to support new drug applications (NDAs).
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology research focusing on the EGFR/MET signaling axis.

Basic Information

Product Name	Amivantamab
CAS No.	2171511-58-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	JNJ-61186372; JNJ 61186372; Amivantamab-vmjw; RYBREVANT® (brand name); Anti-EGFR/c-Met bispecific antibody; EGFR/c-Met BiMAb
EINECS	Contact for details

Quality Control

Our Amivantamab is manufactured and controlled under a stringent quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, adhering to relevant guidelines for advanced therapeutic substances. A detailed Certificate of Analysis (COA) documenting purity (by HPLC), biological activity, endotoxin levels, and other critical quality attributes is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature as per the handling guidelines for biological macromolecules, typically at 2-8°C for liquid formulations or as a lyophilized powder. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled humidity conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (HPLC/LC-MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Assay (Bioassay)	90.0% - 110.0% of labeled potency
Protein Content	90.0% - 110.0% of label claim
Endotoxins	< 1.0 EU/mg
pH	Specification available upon request
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.