Description

3-Aminobicyclo[1.1.1]pentane-1-carbonitrile hydrochloride is a high-value, structurally constrained bicyclic amine derivative, specifically the hydrochloride salt of a 1-aminobicyclo[1.1.1]pentane-1-carbonitrile. This compound matters as a sophisticated and versatile building block in modern organic synthesis, prized for its rigid, three-dimensional scaffold which is instrumental in modulating the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of novel bioactive compounds and as a key intermediate in the synthesis of advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, particularly in fragment-based drug discovery and for creating sp3-rich molecules.
• Medicinal Chemistry Research: Used to introduce the rigid, three-dimensional bicyclo[1.1.1]pentane (BCP) motif, a bioisostere for *para*-substituted benzene rings or tert-butyl groups, to improve metabolic stability, solubility, and binding affinity.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides where the unique BCP core can enhance biological activity and environmental profile.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tool compounds for studying biological pathways and protein function.
• Advanced Material Precursor: Acts as a specialty monomer or cross-linker in the development of polymers with tailored mechanical or thermal properties.
• Academic & Contract Research: Essential for synthetic methodology development and exploration of new chemical space in academic and industrial R&D laboratories.

Basic Information

Product Name	3-Aminobicyclo[1.1.1]pentane-1-carbonitrile hydrochloride
CAS No.	2170371-90-9
Molecular Formula	C7H11ClN2
Molecular Weight	158.63 g/mol
Synonyms	1-Aminobicyclo[1.1.1]pentane-1-carbonitrile hydrochloride; 3-Amino-BCP-1-carbonitrile HCl; Bicyclo[1.1.1]pentane-1-carbonitrile, 1-amino-, hydrochloride; 1-Amino-1-cyanobicyclo[1.1.1]pentane hydrochloride; 1-Cyano-1-aminobicyclo[1.1.1]pentane hydrochloride; 3-Aminobicyclo[1.1.1]pentyl-1-carbonitrile hydrochloride; BCP-NH2-CN hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Aminobicyclo[1.1.1]pentane-1-carbonitrile hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support cGMP-compliant production for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.