Description

1-Bromo-4-Chloro-5-Fluoro-2-Trifluoromethyl-Benzene is a high-value, multi-halogenated aromatic building block designed for advanced synthetic chemistry. This compound is critical for introducing specific halogen substitution patterns into complex molecular architectures, enabling precise control over electronic and steric properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogen pattern contributes to biological activity and environmental stability.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations, facilitating complex bond formations.
• Fluorine Chemistry: The trifluoromethyl and fluorine groups make it a valuable scaffold for exploring fluorinated compounds in medicinal and materials chemistry.
• Chemical Research & Development: Employed in academic and industrial labs for method development, library synthesis, and exploring new chemical spaces.

Basic Information

Product Name	1-Bromo-4-Chloro-5-Fluoro-2-Trifluoromethyl-Benzene
CAS No.	2169320-40-3
Molecular Formula	C7H2BrClF4
Molecular Weight	277.44 g/mol
Synonyms	2-Bromo-5-Chloro-4-Fluoro-α,α,α-Trifluorotoluene; 4-Bromo-1-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzene; 5-Bromo-2-Chloro-1-Fluoro-4-(Trifluoromethyl)Benzene; Benzene, 1-bromo-4-chloro-5-fluoro-2-(trifluoromethyl)-; 1-Bromo-4-chloro-5-fluoro-2-(trifluoromethyl)benzene; BCFFB; BCFTMB
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-5-Fluoro-2-Trifluoromethyl-Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥97.5%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.