Description

Copanlisib-[D8] is a deuterated analog of the phosphatidylinositol 3-kinase (PI3K) inhibitor Copanlisib, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for conducting precise pharmacokinetic, metabolic, and bioanalytical studies, providing critical data for drug development and regulatory submissions. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology research and advanced mass spectrometry applications.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantitative bioanalysis of Copanlisib in biological matrices.
• Critical for conducting drug metabolism and pharmacokinetics (DMPK) studies to understand absorption, distribution, metabolism, and excretion (ADME) profiles.
• Facilitates metabolite identification and profiling studies due to its isotopic signature, aiding in the elucidation of metabolic pathways.
• Supports clinical trial research by ensuring accurate and reliable measurement of Copanlisib concentrations in patient samples.
• Enables method development and validation in analytical laboratories to meet FDA and ICH guidelines for bioanalytical assays.
• Employed in preclinical research to investigate the efficacy and safety profiles of PI3K inhibition in various cancer models.

Basic Information

Product Name	Copanlisib-[D8]
CAS No.	2168537-35-5
Molecular Formula	C32H24D8F3N6O4
Molecular Weight	Contact for details
Synonyms	BAY 80-6946-d8; 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide-d8; Deuterated Copanlisib; Copanlisib D8; Copanlisib (hexadeutero); PI3K Inhibitor-d8; BAY-80-6946-d8; ALIQOPA-d8
EINECS	Contact for details

Quality Control

Our Copanlisib-[D8] is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and absence of impurities. We adhere to relevant industry standards for stable isotope-labeled compounds to support GLP and GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and sealed under an inert atmosphere after opening to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.