Description

Ethyl (1S,3S,4S)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate is a high-purity, stereochemically defined fluorinated cyclohexane derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in the precise spatial arrangement of its functional groups, enabling the construction of complex molecules with defined three-dimensional architecture. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where fluorine substitution and specific stereochemistry are required for optimal biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and bioavailability.
• Asymmetric Catalysis & Ligand Development: Serves as a precursor for chiral ligands and catalysts used in enantioselective synthesis to produce single-isomer compounds.
• Material Science Research: Investigated as a monomer or modifier for creating specialty polymers with unique properties derived from its fluorinated and hydroxylated structure.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of fluorinated fine chemicals.
• Academic & Institutional Research: A valuable tool for methodological studies in organic chemistry, particularly in fluorination chemistry and stereoselective synthesis.

Basic Information

Item	Details
Product Name	Ethyl (1S,3S,4S)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate
CAS No.	2165650-19-9
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	(1S,3S,4S)-Ethyl 4-Fluoro-3-hydroxycyclohexanecarboxylate; Ethyl (1S,3S,4S)-4-Fluoro-3-hydroxycyclohexane-1-carboxylate; (1S,3S,4S)-4-Fluoro-3-hydroxycyclohexanecarboxylic Acid Ethyl Ester; 4-Fluoro-3-hydroxycyclohexanecarboxylic Acid Ethyl Ester (1S,3S,4S)-; (1S,3S,4S)-rel-4-Fluoro-3-hydroxycyclohexanecarboxylic Acid Ethyl Ester; Fluorocyclohexanol Carboxylate Ester; Chiral Fluorinated Cyclohexane Ester
EINECS	Contact for details

Quality Control

Our Ethyl (1S,3S,4S)-4-Fluoro-3-Hydroxycyclohexane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the product from moisture. Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.